Motif ID: FOX{F1,F2,J1}.p2

Z-value: 0.997


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXF1chr16_+_851017340.302.7e-01Click!
FOXJ1chr17_-_716489650.282.9e-01Click!
FOXF2chr6_+_13350670.224.0e-01Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_47468029 1.446 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chrX_-_65176564 1.356 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr22_-_15682555 1.117 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr9_-_14712669 1.023 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr16_-_85099941 0.898 LOC400550
hypothetical LOC400550
chr13_-_45654327 0.870 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_45654296 0.853 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_45654292 0.838 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_18357966 0.835 NM_004864
GDF15
growth differentiation factor 15
chr11_-_104274606 0.794 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr4_-_176971175 0.785 NM_201591
GPM6A
glycoprotein M6A
chr7_+_106292975 0.764 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_-_69267774 0.677 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr9_-_205892 0.673 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr6_-_112682573 0.663 LAMA4
laminin, alpha 4
chr7_+_129693938 0.640 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr1_-_159459999 0.621 NM_001643
APOA2
apolipoprotein A-II
chr7_+_106293112 0.615 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_+_183970093 0.606 NM_031935
HMCN1
hemicentin 1
chr2_+_168383427 0.600 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr9_-_124431634 0.588 NM_001004450
OR1B1
olfactory receptor, family 1, subfamily B, member 1
chr14_-_20562962 0.541 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr9_-_85622366 0.538 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr10_-_50066386 0.531 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr12_-_69837831 0.527 TSPAN8
tetraspanin 8
chr17_+_21946563 0.525 NM_001190452
MTRNR2L1
MT-RNR2-like 1
chr18_+_27152049 0.510 NM_001942
DSG1
desmoglein 1
chr14_-_91268136 0.510 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr1_+_65503011 0.509 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr7_-_122422989 0.502 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr7_+_142590633 0.499 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr3_+_46628928 0.495 NM_001195442
LOC100132146
hypothetical LOC100132146
chr4_+_187424111 0.494 NM_000128
F11
coagulation factor XI
chr2_+_169637255 0.494 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_-_64649608 0.493 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_55942283 0.490 NM_001004744
OR5R1
olfactory receptor, family 5, subfamily R, member 1
chr1_-_57204208 0.489 NM_000066
C8B
complement component 8, beta polypeptide
chr16_-_11282595 0.485 NM_002761
PRM1
protamine 1
chr5_+_147672181 0.476 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr6_-_112682401 0.476 LAMA4
laminin, alpha 4
chr4_+_88973144 0.474 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr4_+_187424336 0.474 F11
coagulation factor XI
chr6_+_21774624 0.474 FLJ22536
hypothetical locus LOC401237
chr1_+_74473672 0.459 NM_015978
TNNI3K
TNNI3 interacting kinase
chr11_-_117305277 0.452 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr12_-_15265490 0.452 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr7_-_48035169 0.434 NM_001030019
NM_152782
SUN3

Sad1 and UNC84 domain containing 3

chr1_+_20269239 0.433 NM_000929
PLA2G5
phospholipase A2, group V
chr14_+_104338423 0.431 ZBTB42
zinc finger and BTB domain containing 42
chr4_+_172971149 0.431 NM_001034845
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr1_+_86707113 0.430 NM_001285
CLCA1
chloride channel accessory 1
chr6_-_160599779 0.426 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr6_-_33085290 0.425 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr6_+_12825818 0.417 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr3_-_10522267 0.416 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr5_+_54434230 0.410 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr2_+_143351695 0.410 KYNU
kynureninase
chr2_+_214984705 0.408 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr22_-_16127520 0.407 CECR3
cat eye syndrome chromosome region, candidate 3
chr12_-_51629874 0.401 KRT8
keratin 8
chr16_+_65868913 0.401 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chrX_+_70232362 0.399 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr7_-_115458010 0.397 NM_001018058
NM_012252
TFEC

transcription factor EC

chr6_+_154373323 0.392 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr12_-_7487989 0.382 NM_174941
CD163L1
CD163 molecule-like 1
chr6_+_44352443 0.376 TMEM151B
transmembrane protein 151B
chr10_+_97749837 0.376 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr12_+_130004404 0.368 NM_198827
GPR133
G protein-coupled receptor 133
chr3_+_173043832 0.367 NM_001164436
TMEM212
transmembrane protein 212
chr1_+_92318449 0.366 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr3_-_10522340 0.364 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr4_+_71142893 0.361 NM_005212
CSN3
casein kappa
chr11_-_117589283 0.360 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr10_+_90511142 0.354 NM_001102469
LIPN
lipase, family member N
chr6_+_26609427 0.351 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr6_+_62341966 0.350 NM_001190706
MTRNR2L9
MT-RNR2-like 9
chr7_+_50318801 0.350 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr7_+_106292932 0.349 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr22_+_22435207 0.348 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr5_-_55564942 0.344 NM_024669
ANKRD55
ankyrin repeat domain 55
chr7_+_142053693 0.344 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr1_+_92190296 0.343 NM_001726
BRDT
bromodomain, testis-specific
chr12_-_94914133 0.342 NM_002108
HAL
histidine ammonia-lyase
chr8_+_120148604 0.339 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_+_88966170 0.335


chr6_-_26038817 0.335 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr20_+_31334601 0.334 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr11_+_55319607 0.333 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr18_+_30327243 0.333 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr1_+_205736095 0.332 NM_000573
NM_000651
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr1_-_155834357 0.331 NM_031282
FCRL4
Fc receptor-like 4
chr12_-_9804682 0.330 NM_001781
CD69
CD69 molecule
chr7_-_87180499 0.325 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr4_+_88939725 0.324 NM_004967
IBSP
integrin-binding sialoprotein
chr17_-_7023378 0.323 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr5_-_42847716 0.321 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrX_+_115215985 0.321 NM_000686
AGTR2
angiotensin II receptor, type 2
chr11_-_55518675 0.318 NM_003697
OR5F1
olfactory receptor, family 5, subfamily F, member 1
chr1_-_167822248 0.316 F5
coagulation factor V (proaccelerin, labile factor)
chr3_-_168674502 0.316 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr10_+_94584449 0.315 NM_001013848
EXOC6
exocyst complex component 6
chr20_-_43996980 0.312 FLJ40606
hypothetical protein LOC643549
chr17_+_64922420 0.310 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr20_-_52120421 0.308 BCAS1
breast carcinoma amplified sequence 1
chr7_-_142369519 0.304 KEL
Kell blood group, metallo-endopeptidase
chr11_-_5178505 0.303 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr20_+_16676997 0.302 NM_020157
OTOR
otoraplin
chr12_-_14929991 0.299 NM_000900
NM_001190839
MGP

matrix Gla protein

chr20_-_49612574 0.296 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr12_-_51332214 0.295 NM_000423
KRT2
keratin 2
chr2_+_143351536 0.294 NM_001032998
NM_003937
KYNU

kynureninase

chr1_-_244796169 0.294 NM_022366
TFB2M
transcription factor B2, mitochondrial
chr4_+_35962038 0.292 NM_001170700
DTHD1
death domain containing 1
chr1_+_150753601 0.292 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr11_+_5925152 0.292 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr4_+_91375204 0.292 NM_207491
FAM190A
family with sequence similarity 190, member A
chr20_+_51023159 0.287 TSHZ2
teashirt zinc finger homeobox 2
chr7_-_107230867 0.282 NM_000111
SLC26A3
solute carrier family 26, member 3
chr19_-_38052481 0.281 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr5_-_180009205 0.280 FLT4
fms-related tyrosine kinase 4
chr2_+_161980865 0.280 NM_006593
TBR1
T-box, brain, 1
chr5_-_27074407 0.280 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr10_+_96512447 0.279 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr7_-_140270749 0.278 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr18_+_30327341 0.277 DTNA
dystrobrevin, alpha
chr17_+_53587492 0.276 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr11_+_59027624 0.275 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr18_+_59374372 0.272 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr4_-_82612049 0.272 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr5_-_169657360 0.270 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_36276987 0.270 NM_000223
KRT12
keratin 12
chr2_-_162717159 0.270 NM_002054
GCG
glucagon
chr12_+_92595281 0.269 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr6_-_2696152 0.269 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr5_-_20024050 0.268 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr1_-_245763763 0.266 NM_198074
OR2C3
olfactory receptor, family 2, subfamily C, member 3
chr21_-_14840506 0.265 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_-_101835026 0.265 PAH
phenylalanine hydroxylase
chr8_-_16094591 0.264 NM_002445
NM_138715
NM_138716
MSR1


macrophage scavenger receptor 1


chr11_+_48194937 0.262 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr5_-_110090264 0.261 NM_001039763
TMEM232
transmembrane protein 232
chr7_-_142369534 0.261 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr10_+_4995453 0.250 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_-_155788775 0.250 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr5_-_169657312 0.249 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr20_-_43609409 0.249 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr7_-_112513379 0.249 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr1_-_244796062 0.248 TFB2M
transcription factor B2, mitochondrial
chr11_-_102331643 0.248 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr9_+_128764324 0.247 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr2_-_21084077 0.247 APOB
apolipoprotein B (including Ag(x) antigen)
chr15_+_56217686 0.246 NM_020980
AQP9
aquaporin 9
chr9_+_132990760 0.242 NM_005085
NUP214
nucleoporin 214kDa
chr11_+_60309396 0.242 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr6_+_32229599 0.242 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr7_-_25234582 0.242 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_244796261 0.242 NM_001139459
NM_152609
CNST

consortin, connexin sorting protein

chr6_-_31740466 0.241 GPANK1
G patch domain and ankyrin repeats 1
chrX_-_15242589 0.241 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr12_+_98565663 0.241 NM_153364
FAM71C
family with sequence similarity 71, member C
chr2_+_1396239 0.241 NM_000547
NM_175719
TPO

thyroid peroxidase

chr5_-_180009178 0.241 FLT4
fms-related tyrosine kinase 4
chr1_-_195302973 0.240 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr19_+_15612706 0.240 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr1_+_244796426 0.240 CNST
consortin, connexin sorting protein
chr4_+_74488910 0.239 ALB
albumin
chr15_-_38387266 0.238 PLCB2
phospholipase C, beta 2
chr6_+_136214495 0.236 NM_018945
PDE7B
phosphodiesterase 7B
chr16_+_11346780 0.234 NM_152308
C16orf75
chromosome 16 open reading frame 75
chr1_+_205344200 0.234 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr12_-_61615124 0.233 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_+_32230172 0.233 PPT2
palmitoyl-protein thioesterase 2
chr7_-_126670804 0.233 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr13_-_38462857 0.233 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr1_+_244796441 0.232 CNST
consortin, connexin sorting protein
chr4_-_140443061 0.232 NM_001184987
NM_001184988
NM_001184989
NM_001184990
NDUFC1



NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa



chr20_+_30061905 0.229 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr1_+_195503956 0.228 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr2_-_165133239 0.228 GRB14
growth factor receptor-bound protein 14
chr5_-_180009150 0.227 FLT4
fms-related tyrosine kinase 4
chr12_+_120055013 0.226 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr12_-_11439752 0.225 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr5_-_169657395 0.224 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr18_+_53170718 0.224 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr17_-_72151314 0.224 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr15_-_38387357 0.224 PLCB2
phospholipase C, beta 2
chr1_+_245779018 0.223 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr8_+_100025806 0.222 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr6_-_168222645 0.220 NM_024919
FRMD1
FERM domain containing 1
chr22_+_48951286 0.220 NM_001160300
NM_052839
PANX2

pannexin 2

chr4_-_155531898 0.218 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr6_-_112682459 0.217 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr17_-_31104009 0.217 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr16_+_54782802 0.216 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr4_-_100575313 0.215 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr7_+_113513828 0.213 FOXP2
forkhead box P2
chr20_-_22514092 0.212 NM_153675
FOXA2
forkhead box A2
chr7_-_93041971 0.212 NM_001164737
NM_001742
CALCR

calcitonin receptor

chr12_-_7709734 0.211 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr17_+_7180571 0.210 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.45 4.84e-07 GO:0007608 sensory perception of smell
2.31 1.96e-06 GO:0007606 sensory perception of chemical stimulus
1.58 2.39e-05 GO:0003008 system process
1.83 1.24e-04 GO:0007600 sensory perception
1.23 6.22e-03 GO:0032501 multicellular organismal process
1.52 9.56e-03 GO:0050877 neurological system process
3.79 2.85e-02 GO:0010951 negative regulation of endopeptidase activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 2.52e-07 GO:0071944 cell periphery
1.35 2.80e-07 GO:0005886 plasma membrane
1.54 4.54e-07 GO:0005576 extracellular region
4.13 3.06e-03 GO:0031983 vesicle lumen
4.22 5.32e-03 GO:0031093 platelet alpha granule lumen
4.13 6.70e-03 GO:0034774 secretory granule lumen
1.54 7.92e-03 GO:0044421 extracellular region part
3.97 1.04e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.71 1.08e-02 GO:0031091 platelet alpha granule
1.19 1.18e-02 GO:0016021 integral to membrane
1.19 1.26e-02 GO:0031224 intrinsic to membrane
1.60 1.49e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.87 3.18e-10 GO:0004888 transmembrane receptor activity
2.02 1.73e-08 GO:0004930 G-protein coupled receptor activity
2.44 4.36e-07 GO:0004984 olfactory receptor activity
1.62 5.21e-07 GO:0004872 receptor activity
1.44 2.78e-04 GO:0004871 signal transducer activity
1.44 2.78e-04 GO:0060089 molecular transducer activity
2.91 1.31e-02 GO:0019955 cytokine binding
3.01 3.74e-02 GO:0004867 serine-type endopeptidase inhibitor activity